What is Epithelioid Mesothelioma: Understanding the Most Common Type of Mesothelioma

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Mesothelioma is a rare and aggressive form of cancer that affects the lining of the lungs, abdomen, and other organs. Among the different types of mesothelioma, epithelioid mesothelioma is the most common. In this article, we will delve into what epithelioid mesothelioma is, its symptoms, diagnosis, treatment options, and address some frequently asked questions surrounding this condition.

Mesothelioma, a cancer caused primarily by asbestos exposure, is known for its aggressive nature and late-stage diagnosis. Epithelioid mesothelioma is a subtype that accounts for approximately 70% of all mesothelioma cases. It is characterized by the presence of epithelial cells, which are the cells that line the internal and external surfaces of the body’s organs.

Understanding Epithelioid Mesothelioma

Epithelioid mesothelioma is the most favorable subtype among the three major types of mesothelioma. It typically has a better prognosis compared to sarcomatoid or biphasic mesothelioma. These tumors tend to grow and spread more slowly, allowing for a better response to treatment.

Symptoms and Diagnosis

The symptoms of epithelioid mesothelioma can vary depending on the location of the tumor. Common symptoms include persistent cough, chest pain, shortness of breath, fatigue, and unexplained weight loss. However, these symptoms can be easily mistaken for other respiratory or digestive conditions, leading to delayed diagnosis.

Diagnosing epithelioid mesothelioma requires a multidisciplinary approach. It usually involves a combination of imaging tests, such as X-rays, CT scans, and MRIs, as well as a biopsy to examine the tissue samples under a microscope. Early and accurate diagnosis is crucial for determining the most appropriate treatment plan.

Treatment Options for Epithelioid Mesothelioma

Treatment options for epithelioid mesothelioma depend on various factors, including the stage of the cancer, the patient’s overall health, and the extent of tumor growth. The primary treatment modalities for epithelioid mesothelioma include surgery, chemotherapy, and radiation therapy.

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Surgery aims to remove the tumor and any affected surrounding tissue. It can involve procedures like a pleurectomy/decortication (P/D) or an extrapleural pneumonectomy (EPP) for pleural mesothelioma, or a peritonectomy for peritoneal mesothelioma. Chemotherapy and radiation therapy are often used in combination with surgery to target any remaining cancer cells and reduce the risk of recurrence.

Emerging treatment approaches, such as immunotherapy and targeted therapy, show promise in improving outcomes for epithelioid mesothelioma patients. Clinical trials are ongoing to further explore these innovative treatment options.

Frequently Asked Questions (FAQ)

What are the potential causes of epithelioid mesothelioma?

The primary cause of epithelioid mesothelioma is exposure to asbestos, a naturally occurring mineral that was widely used in various industries until its ban in many countries. Asbestos fibers, when inhaled or ingested, can accumulate in the body’s organs and trigger cancerous changes in the mesothelial cells over time.

How is epithelioid mesothelioma different from other types of mesothelioma?

Epithelioid mesothelioma differs from other types of mesothelioma, such as sarcomatoid or biphasic, based on the type of cells involved. Epithelioid mesothelioma is characterized by the presence of well-differentiated epithelial cells, which tend to grow and spread more slowly compared to the other subtypes.

Can epithelioid mesothelioma be cured?

While there is currently no known cure for mesothelioma, including epithelioid mesothelioma, treatment options have improved over the years, offering better outcomes and extended life expectancy for patients. Early detection, prompt treatment, and advancements in medical research provide hope for improved survival rates in the future.


Epithelioid mesothelioma is the most common subtype of mesothelioma, characterized by well-differentiated epithelial cells. Though mesothelioma remains a challenging cancer to treat, advancements in diagnostic techniques, surgical interventions, and emerging treatment options have provided hope for improved outcomes. Early detection and a comprehensive treatment approach are vital in managing this aggressive disease. By raising awareness and supporting ongoing research, we can make significant strides toward a future with better outcomes for those affected by epithelioid mesothelioma.

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Remember, if you or someone you know is experiencing symptoms or has been exposed to asbestos, it is crucial to consult with a medical professional for proper evaluation and guidance.

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